Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans.
نویسندگان
چکیده
People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting, then decoded neural activity in later sessions in which we applied stimulation during learning. Stimulation increased encoding-state estimates and recall if delivered when the classifier indicated low encoding efficiency but had the reverse effect if stimulation was delivered when the classifier indicated high encoding efficiency. Higher encoding-state estimates from stimulation were associated with greater evidence of neural activity linked to contextual memory encoding. In identifying the conditions under which stimulation modulates memory, the data suggest strategies for therapeutically treating memory dysfunction.
منابع مشابه
Comparison of the effect of Transcranial Direct Current Stimulation (tDCS (and Transcranial Random Noise Stimulation (tRNS (combined with cognitive training on working memory performance of people with attention deficit/hyperactivity disorder
This study aimed to comparison of the effect of Transcranial Direct Current Stimulation (tDCS) and Transcranial Random Noise Stimulation (tRNS) combined with cognitive training on working memory performance of people with attention deficit/hyperactivity disorder. For this purpose, 45 children with attention deficit hyperactivity disorder in zahedan city were purposefully selected as the researc...
متن کاملW6: Transcranial Direct Current Stimulation Workshop
It is an Intensive 1-day course for introducing utilizing transcranial direct current stimulation (tDCS) in an applied format. This technique is a noninvasive brain stimulation that uses direct electrical currents over the head to stimulate specific parts of the brain which modulates neuronal activity. It has strong potentiality in the field of medical and neuroscientific research. Anodal stimu...
متن کاملThe Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
Introduction: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial di...
متن کاملElectrical Stimulation Modulates High γ Activity and Human Memory Performance
Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect...
متن کاملEnhancement of Visuospatial Working Memory by Transcranial Direct Current Stimulation (tDCS) on Prefrontal and Parietal Cortices
Objective: Previous studies have reported dorsolateral prefrontal cortex (DLPFC) and posterior parietal (PPC) activation during the performance of spatial working memory (SWM), so we decided to investigate the comparison of Transcranial Direct current stimulation (tDCS) effect between these two areas. Methods: Fifty-four healthy right-handed students (27 female, 27 male; age= 24.3±.2 years) w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current biology : CB
دوره 27 9 شماره
صفحات -
تاریخ انتشار 2017